• Product NameCYP3A4 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntibodies were purified by affinity purification using immunogen.
• ApplicationsWB IHC
• Species ReactivityHu Ms
• SpecificityThe antibody detects endogenous level of total CYP3A4 protein.
• Immunogen TypeRecombinant Protein
• Immunogen DescriptionRecombinant protein of human CYP3A4.
• Target NameCYP3A4
• Alternative Names    CP33; CP34; CYP3A; CYP3A3; HLP
• Accession No. Swiss-Prot:P08684
  NCBI Gene ID:1576
• UniprotP08684
• Gene ID1576;
• SDS-PAGE MW 57kD
• Concentration 1.0mg/ml
• Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500 - 1:2000
  Immunohistochemistry: 1:50 - 1:200
   

Cytochrome P450 3A(CYP3A) belongs to the cytochrome P450 family and the enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications.CYP3A expression determines impairment of drug absorption and efficient systemic clearance in a tissue-specific manner(PMID:17975676).This antibody is specific to CYP3A4.

• Western blot analysis of extracts of Mouse liver, using CYP3A4 antibody.
• Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using CYP3A4 Antibody #32703

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting