• Product NameGluR6 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB IHC
• Species ReactivityHu Ms
• SpecificityThe antibody detects endogenous levels of total GluR6 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from human GluR6.
• Target NameGluR6
• Alternative Names    EAA4; GLR6; MGC74427; bA487F5.1 (glutamate receptor; ionotropic
• Accession No. Swiss-Prot: O15303
  NCBI Gene ID: 2916
• UniprotO15303
• Gene ID2916;
• SDS-PAGE MW 100kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  Immunohistochemistry: 1:50~1:100
  

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity. Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.

Inga Everts, J. Neurosci., Feb 1999; 19: 916.
Gregory D. Salinas, J. Biol. Chem., Dec 2006; 281: 40164 - 40173.
Sheng Yan, J. Neurosci., Jan 2004; 24: 679.
Xiao-Mei Liu, J. Biol. Chem., Jun 2006; 281: 17432 - 17445.

• Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR6 antibody #33389.
• Western blot analysis of extracts from mouse brain, using GluR6 antibody #33389.
• Western blot analysis of extracts from HepG2 cells (Lane 2), using mGluR6 antiobdy #33389. The lane on the left is treated with synthesized peptide.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting