• Product NameACTR-1C Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsIHC IF
• Species ReactivityHu Ms
• SpecificityThe antibody detects endogenous levels of total ACTR-1C protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from internal of human ACTR-1C.
• Target NameACTR-1C
• Alternative Names    Activin receptor type-1C; EC 2.7.11.30; ACTR-IC; Activin receptor-like kinase 7; ALK-7
• Accession No. Swiss-Prot: Q8NER5
  NCBI Gene ID: 130399
• UniprotQ8NER5
• Gene ID130399;
• SDS-PAGE MW 55kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:50~1:100
  Immunofluorescence: 1:100~1:500

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Bondestam J., Cytogenet. Cell Genet. 95:157-162(2001).
Roberts H.J., Biol. Reprod. 68:1719-1726(2003).
Hillier L.W., Nature 434:724-731(2005).

• Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ACTR-1C antibody #33973.
• Immunofluorescence analysis of COS-7 cells, using ACTR-1C antibody #33973.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting