• Product NameMKL1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total MKL1 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from N-terminal of human MKL1.
• Target NameMKL1
• Alternative Names    Myocardin-related transcription factor A; MRTF-A; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein;
• Accession No. Swiss-Prot: Q969V6
  NCBI Gene ID: 57591
• UniprotQ969V6
• Gene ID57591;
• SDS-PAGE MW 99kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  
  

Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation By similarity.

Ma Z., Nat. Genet. 28:220-221(2001).
Mercher T., Proc. Natl. Acad. Sci. U.S.A. 98:5776-5779(2001).
Nagase T., DNA Res. 7:65-73(2000).

• Western blot analysis of extracts from HeLa cells and HUVEC cells, using MKL1 antibody #34018.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting