• Product NameCDH23 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsIF
• Species ReactivityHu Ms
• SpecificityThe antibody detects endogenous levels of total CDH23 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from internal of human CDH23.
• Target NameCDH23
• Alternative Names    DFNB12; USH1D; cadherin 23 C1; cadherin 23 C2; cadherin related 23
• Accession No. Swiss-Prot: Q9H251
  NCBI Gene ID: 64072
• UniprotQ9H251
• Gene ID64072;
• SDS-PAGE MW 370kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• 
  
  Immunofluorescence: 1:100~1:500

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.

Bolz H., Nat. Genet. 27:108-112(2001).
Clark H.F., Genome Res. 13:2265-2270(2003).
Bork J.M., Am. J. Hum. Genet. 68:26-37(2001).

• Immunofluorescence analysis of HeLa cells, using CDH23 antibody #34179.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting