Description
- Product NameABCA1 Antibody
- Host SpeciesRabbit
- ClonalityPolyclonal
- PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- ApplicationsWB
- Species ReactivityHu Ms Rt
- SpecificityThe antibody detects endogenous level of total ABCA1 protein.
- Immunogen TypePeptide-KLH
- Immunogen DescriptionPeptide sequence around aa.2253~2257(D-E-K-V-K) derived from Human ABCA1.
- Target NameABCA1
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Alternative Names TGD; ABC1; CERP; ABC-1;
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Accession No. Swiss-Prot: O95477
NCBI Protein: NP_005493.2
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UniprotO95477
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Gene ID19;
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Concentration 1.0mg/ml
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Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
Kaplan R., Gan X., Menke J.G. Lipid Res. 43:952-959(2002)
Hamon Y., Trompier D., Ma Z., Venegas V. PLoS ONE 1:E120-E120(2006)
Singaraja R.R., Kang M.H., Vaid K. Berthiaume L. Res. 105:138-147(2009)
Published Papers
Drug metabolism-related gene ABCA1 augments temozolomide chemoresistance and immune infiltration abundance of M2 macrophages in gliomaInEur J Med ResOn2023 Sep 25byYuanliang Yan?#?1,?Yuanhong Liu et al..PMID:?37749600, , (2023),
PMID: 37749600
5-HT2A Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Steatosis In J Atheroscler Thromb on 2022 Mar 1 by Yingying Ma, Xiurui Liang,et al..PMID: 33536397, , (2022),
PMID: 33536397
Chronic Administration of Mitochondrion-Targeted Peptide SS-31 Prevents Atherosclerotic Development in ApoE Knockout Mice Fed Western Diet.In PLoS One on 2017 Sep 29 by Meng Zhang , Hongting Zhao,et al..PMID: 28961281, , (2017),
PMID: 28961281
Quercetin Regulates Hepatic Cholesterol Metabolism by Promoting Cholesterol-To-Bile Acid Conversion and Cholesterol Efflux in Rats.In Nutr Res on 2016 Mar by Min Zhang , Zongkai Xie et al..PMID:26923514, , (2016),
PMID: 26923514
View All Published Papers
Iron together with lipid downregulates protein levels of ceruloplasmin in macrophages associated with rapid foam cell formation.In J Atheroscler Thromb on 2016 Oct 1 by Qi Wang , Jiajie Ji et al..PMID: 27040361, , (2016),
PMID: 27040361
Pioglitazone reduces lipid droplets in cholesterolosis of the gallbladder by increasing ABCA1 and NCEH1 expression.In Mol Cell Biochem on 2015 Jan by Jing-Min Wang , Dong Wang et al..PMID:25280398, , (2015),
PMID: 25280398
Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.In Molecules on 2015 Dec 1 by Shuangying Hao, Jiajie Ji et al..PMID: 26633327, , (2015),
PMID: 26633327
22 (R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ�CLXRα�CABCA1 pathway in cholesterosis of the gallbladder.In Biochem Biophys Res Commun on 2014 Apr 25 by Jing-Min Wang, Dong Wang et al..PMID:24704452 , , (2014),
PMID: 24704452
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