• Product NameCCR5(CD195) Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
• ApplicationsWB
• Species ReactivityHu Ms
• SpecificityThe antibody detects endogenous level of total CCR5(CD195) protein.
• Immunogen TypePeptide-KLH
• Immunogen DescriptionPeptide sequence around aa.11~15(D-I-N-Y-Y) derived from Human CCR5(CD195).
• Target NameCCR5(CD195)
• Alternative Names    CKR5; CD195; CKR-5
• Accession No. Swiss-Prot: P51681
  NCBI Protein: NP_000570.1
• UniprotP51681
• Gene ID1234;
• Concentration 1.0mg/ml
• Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

• Predicted MW: 41kd
  Western blotting: 1:500~1:1000
  

Receptor for a number of inflammatory CC-chemokines including MIP-1-a, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

Samson M., Labbe O., Mollereau C. Biochemistry 35:3362-3367(1996)
Raport C.J., Gosling J., Schweichart V.L. J. Biol. Chem. 271:17161-17166(1996)
Combadiere C., Ahuja S.K., Tiffany H.L., Murphy P.M.J. Leukoc. Biol. 60:147-152(1996)

• Western blot analysis of extracts from Mouse liver tissue using CCR5(CD195) Antibody #21666.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting