Welcome to Sabbiotech!     
Email:info@signalwayantibody.com
Welcome Login Register My Cart(0,$0.00)
Location： Home > Polyclonal Antibodies > IGF-1R(Ab-1161) Antibody

IGF-1R(Ab-1161) Antibody#21080

Datasheet PDF
Availability： Yes
Total Amount:$
ADD TO CART
Detail Pictures Description Publish(5) Other
Product Detail

Product NameIGF-1R(Ab-1161) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

ApplicationsWB IHC IF

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of total IGF-1R protein.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around aa.1159~1163 (D-I-Y-E-T) derived from Human IGF-1R .

Target NameIGF-1R

ConjugateUnconjugated

Other Names Insulin-like growth factor I receptor; CD221; IGF1R; kinase IGF1R;

Accession NoSwiss-Prot: P08069
NCBI Protein: NP_000866.1

Uniprot P08069

Gene ID 3480;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details
Predicted MW: 200 95 kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
Western blot analysis of extracts from 293 cells using IGF-1R(Ab-1161) Antibody #21080 and the same antibody preincubated with blocking peptide.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IGF-1R(Ab-1161) Antibody #21080(left) or the same antibody preincubated with blocking peptide(right).
Immunofluorescence staining of methanol-fixed MCF cells using IGF-1R(Ab-1161) Antibody #21080.
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Li S, et al. (1994) J Biol Chem; 269(51).
Hernandez-Sanchez C, et al. (1995) J Biol Chem.

If you have published an article using product 21080, please notify us so that we can cite your literature.

et al,Sexual Dimorphism in Expression of Insulin and Insulin-Like Growth Factor-I Receptors in Developing Rat Cerebellum. , (2013),
PMID: 23322319
et al,Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer , (2012),
PMID: 22969971
et al,The effects of maternal diabetes on expression of insulin-like growth factor-1 and insulin receptors in male developing rat hippocampus.In Brain Struct Funct on 2013 Jan by Hami J, Sadr-Nabavi A,et al..PMID:22241286 , (2013),
PMID: 22241286
et al,Sexual dimorphism in expression of insulin and insulin-like growth factor-I receptors in developing rat cerebellum.In Cell Mol Neurobiol on 2013 Apr by Haghir H, Rezaee AA,et al..PMID:23322319 , (2013),
PMID: 23322319
et al,Circular RNA_PDHX Promotes the Proliferation and Invasion of Prostate Cancer by Sponging MiR-378a-3p. In Front Cell Dev Biol on 2021 Jan 28 by Yuanshen Mao, Wenfeng Li,et al..PMID:33634097 , (2021),
PMID: 33634097

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

QUICK NAV

New Products

Cell Signal Transduction

Cancer

Stem Cell

Neuroscience

Help and Support

Contact Us

Terms

Privacy Policy

support

Distributors