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Location： Home > Recombinant Rabbit Monoclonal Antibodies > MMP12 Rabbit mAb

MMP12 Rabbit mAb#48662

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Product Detail

Product NameMMP12 Rabbit mAb

Clone No.SR03-23

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, IP, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesEC 3.4.24.65 antibody
HME antibody
Macrophage elastase antibody
Macrophage metalloelastase antibody
Macrophage metaloelastase antibody
Matrix metallopeptidase 12 (macrophage elastase) antibody
Matrix metalloprotease 12 antibody
Matrix metalloproteinase-12 antibody
ME antibody
MGC138506 antibody
MME antibody
MMP 12 antibody
MMP-12 antibody
Mmp12 antibody
MMP12_HUMAN antibody

Accession NoSwiss-Prot#:P39900

Uniprot P39900

Gene ID 4321;

Calculated MW54/45/22 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100
Western blot analysis of MMP12 on different cell lysates using anti-MMP12 antibody at 1/1,000 dilution. Positive control:
Lane 1: A549
Lane 2: Hela
Lane 3: MCF-7
Lane 4: THP-1
Immunohistochemical analysis of paraffin-embedded human breast carcinomna tissue using anti-MMP12 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-MMP12 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of A549 cells with MMP12 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 (also designated macrophage metalloelastase) is produced in alveolar macrophages and degrades elastin. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders.

If you have published an article using product 48662, please notify us so that we can cite your literature.

et al,A pyroptosis-related gene signature that predicts immune infiltration and prognosis in colon cancerInFront OncolOn2023 Jul 12byMingjian Wu?1,?Shuai Hao et al..PMID:?37503314 , (2023),
PMID: 37503314

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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