Product Detail
Product NameOGT (Phospho-Ser20) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsCustom antibody
Species ReactivityHu Ms
Immunogen TypePeptide-KLH
Target NameOGT
ConjugateUnconjugated
Other NamesUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Accession Nouniprot:O15294
Calculated MW117kDa
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20��C for long term preservation (recommended). Store at 4��C for short term use.
Application Details
Western blotting: 1:500~1:1000
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539, PubMed:23103939, PubMed:21240259, PubMed:21285374, PubMed:15361863). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:21285374). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539).
If you have published an article using product SAB498P, please notify us so that we can cite your literature.
et al,Targeting cTRIP12 counteracts ferroptosis resistance and augments sensitivity to immunotherapy in pancreatic cancer.
, (2025),
PMID:
40154160
Yes
