• Product NameCDKN1C Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total CDKN1C protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthetic peptide corresponding to residues near the N terminal of human cyclin-dependent kinase inhibitor 1C (p57, Kip2)
• Target NameCDKN1C
• Alternative Names    BWS; WBS; p57; BWCR; KIP2; IMAGE
• Accession No. Swiss-Prot#: P49918
  NCBI Gene ID: 1028
  Gene Accssion: NP_000067
• UniprotP49918
• Gene ID1028;
• Concentration 0.6mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• Immunohistochemistry: 1:25-1:100

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

• Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using #36788 at dilution 1/15.
• Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #36788 at dilution 1/15.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting