• Product NameHCN2 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total HCN2 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthetic peptide corresponding to residues near the C terminal of human hyperpolarization activated cyclic nucleotide-gated potassium channel 2
• Target NameHCN2
• Alternative Names    BCNG2; HAC-1; BCNG-2
• Accession No. Swiss-Prot#: Q9UL51
  NCBI Gene ID: 610
  Gene Accssion: NP_001185
• UniprotQ9UL51
• Gene ID610;
• Concentration 2.7mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• Immunohistochemistry: 1:50-1:200

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.

• Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using #36922 at dilution 1/80.
• Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using #36922 at dilution 1/80.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting