• Product NameTOP1MT Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total TOP1MT protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthetic peptide corresponding to a region derived from internal residues of human topoisomerase (DNA) I, mitochondrial
• Target NameTOP1MT
• Alternative Names    TOP1M; TOP1MT; topoisomerase (DNA) I; mitochondrial
• Accession No. Swiss-Prot#: Q969P6
  NCBI Gene ID: 116447
  Gene Accssion: NP_001245375
• UniprotQ969P6
• Gene ID116447;
• Concentration 0.5mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• Immunohistochemistry: 1:15-1:50

This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

• Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue using #37052 at dilution 1/15.
• Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using #37052 at dilution 1/15.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting