• Product NameFAT4 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total FAT4 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthetic peptide corresponding to residues near the C terminal of human FAT tumor suppressor homolog 4 (Drosophila)
• Target NameFAT4
• Alternative Names    FATJ; FAT-J; CDHF14; CDHR11; NBLA00548
• Accession No. Swiss-Prot#: Q6V0I7
  NCBI Gene ID: 79633
  Gene Accssion: NP_078858
• UniprotQ6V0I7
• Gene ID79633;
• Concentration 0.7mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• Immunohistochemistry: 1:25-1:100

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by γ?secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane?associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.

• Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #37293 at dilution 1/20.
• Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using #37293 at dilution 1/20.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting