• Product NameARHGEF6 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification.
• ApplicationsIHC
• Species ReactivityHu Ms Rt
• SpecificityThe antibody detects endogenous levels of total ARHGEF6 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthetic peptide corresponding to a region derived from internal residues of human Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
• Target NameARHGEF6
• Alternative Names    PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX
• Accession No. Swiss-Prot#: Q15052
  NCBI Gene ID: 9459
  Gene Accssion: NP_004831
• UniprotQ15052
• Gene ID9459;
• Concentration 2.6mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• Immunohistochemistry: 1:50-1:200

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.

• Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using #37342 at dilution 1/70.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting