- Product NameLuminespib (AUY-922, NVP-AUY922)
- Brief DescriptionInhibitors
- Purification98.97%
- Biological ActivityAUY922 (NVP-AUY922) is a potent, novel synthetic resorcinylic isoxazole amide inhibitor of heat shock protein 90 (HSP90). It is a small molecular with the formula of C26H31N3O5 and molecular weight of 465.5. It has a much higher af?nity for Hsp90 and can be ound to the ATP binding site of Hsp90 at the N-terminal domain. Heat shock protein 90 (HSP90) is a molecular chaperone essential for the stability of key regulators of cell growth and survival. NVP-AUY922 potently inhibits the proliferation of gastric Y cell lines with with GI50 values of approximately 2 to 40 nmol/L and significantly induces the degradation of growth factor receptors and other client proteins.
- Target NameHSP inhibitor
- CAS No. 747412-49-3
- Calculated MW 465.54
- Formulation C26H31N3O5
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
