• Product NameObatoclax Mesylate (GX15-070)
• Brief DescriptionInhibitors
• Purification99.67%
• Biological ActivityObatoclax (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
• Target NameBcr-Abl antagonist
• CAS No. 803712-79-0
• Calculated MW 413.49
• Formulation C20H19N3OCH4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC(=C(N1)/C=C\2/C(=C/C(=C/3\C=C4C=CC=CC4=N3)/N2)OC)C.CS(=O)(=O)O
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:Bcl-2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 83 mg/mL (200.73 mM)
  Appearance:RedPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nguyen M, et al. Proc Natl Acad Sci, 2007, 104(49), 19512-191517.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting