• Product NameWP1130
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDegrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT).
• Target NameBcr-Abl inhibitor
• CAS No. 856243-80-6
• Calculated MW 384.27
• Formulation C19H18BrN3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:Bcr-Abl
  Boling pt:
  Melting pt:
  Solubility:DMSO:77 mg/mL (200.37 mM)Ethanol:18 mg/mL (46.84 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bartholomeusz GA, et al. Blood, 2007, 109(8), 3470-3478.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting