• Product NameNSC59984
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityNSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
• Target Namep53 inhibitor
• CAS No. 803647-40-7
• Calculated MW 265.27
• Formulation C12H15N3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1CCN(CC1)C(=O)/C=C/C2=CC=C(O2)[N+](=O)[O-]
  Pathways:Apoptosis
  Receptor:p53
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 53 mg/mL (199.79 mM) DMSO: 53 mg/mL (199.79 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang S., et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75(18):3842-52.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting