• Product NameMLKL (phospho S345) Rabbit mAb
• Host SpeciesRabbit
• ClonalityMonoclonal
• Clone No.JM92-37
• PurificationProA affinity purified
• ApplicationsIHC
• Species ReactivityMs
• Immunogen DescriptionSynthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL.
• Alternative Names    9130019I15Rik antibody
  FLJ34389 antibody
  hMLKL antibody
  Mixed lineage kinase domain like antibody
  Mixed lineage kinase domain like protein antibody
  Mixed lineage kinase domain like pseudokinase antibody
  Mixed lineage kinase domain-like protein antibody
  Mlkl antibody
  MLKL_HUMAN antibody
  
• Accession No. Swiss-Prot#:Q9D2Y4
• UniprotQ9D2Y4
• Gene ID74568;
• Calculated MW 54 kDa
• Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• Storage Store at -20˚C

• 
  IHC: 1:50-1:100
  
  
  

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

• Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-MLKL (phospho S345) antibody. Counter stained with hematoxylin.
• Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-MLKL (phospho S345) antibody. Counter stained with hematoxylin.
• Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-MLKL (phospho S345) antibody. Counter stained with hematoxylin.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting