• Product NamePhospho-alpha Synuclein (S129) Rabbit mAb
• Host SpeciesRabbit
• ClonalityMonoclonal
• Clone No.JB22-44
• PurificationProA affinity purified
• ApplicationsWB,ICC,IF,IHC
• Species ReactivityHu, Ms, Rt
• Immunogen DescriptionSynthetic phospho-peptide corresponding to residues surrounding Ser129 of human alpha Synuclein.
• Alternative Names    Alpha synuclein antibody
  Alpha-synuclein antibody
  Alpha-synuclein, isoform NACP140 antibody
  alphaSYN antibody
  MGC105443 antibody
  MGC110988 antibody
  MGC127560 antibody
  MGC64356 antibody
  NACP antibody
  Non A beta component of AD amyloid antibody
  Non A4 component of amyloid antibody
  Non A4 component of amyloid precursor antibody
  Non-A beta component of AD amyloid antibody
  Non-A-beta component of alzheimers disease amyloid , precursor of antibody
  Non-A4 component of amyloid precursor antibody
  Non-A4 component of amyloid, precursor of antibody
  OTTHUMP00000218549 antibody
  OTTHUMP00000218551 antibody
  OTTHUMP00000218552 antibody
  OTTHUMP00000218553 antibody
  OTTHUMP00000218554 antibody
  PARK 1 antibody
  PARK 4 antibody
  PARK1 antibody
  PARK4 antibody
  Parkinson disease (autosomal dominant, Lewy body) 4 antibody
  Parkinson disease familial 1 antibody
  SNCA antibody
  Snca synuclein, alpha (non A4 component of amyloid precursor) antibody
  SYN antibody
  Synuclein alpha antibody
  Synuclein alpha 140 antibody
  Synuclein, alpha (non A4 component of amyloid precursor) antibody
  SYUA_HUMAN antibody
  
• Accession No. Swiss-Prot#:P37840
• UniprotP37840
• Gene ID6622;
• Calculated MW 14 kDa
• Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• Storage Store at -20˚C

• 
  IHC: 1:50-1:200
  ICC: 1:50-1:200
  
  

The synuclein family members, including α-synuclein (also designated NACP for non-β-Amyloid component) and β-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. α-synuclein is localized to neuronal cell bodies and synapses. α-synuclein was first identified as a component of Alzheimer's disease amyloid plaques. Abnormal platelet function in Alzheimer's disease has been demonstrated. During megakaryocytic differentiation α-synuclein has been found to be upregulated, while β-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of α-synuclein has been found in patients with early onset Parkinson's disease.

• Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-Phospho-alpha Synuclein (S129) antibody. Counter stained with hematoxylin.
• Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Phospho-alpha Synuclein (S129) antibody. Counter stained with hematoxylin.
• Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Phospho-alpha Synuclein (S129) antibody. Counter stained with hematoxylin.
• ICC staining Phospho-alpha Synuclein (S129) in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
• ICC staining Phospho-alpha Synuclein (S129) in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
• ICC staining Phospho-alpha Synuclein (S129) in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting