Ks 19.1 represents an excellent marker to discriminate glandular epithelial carcinoma from those of different origin. No reaction with hepatocellular carcinoma. Polypeptide reacting: Mr 40 000 polypeptide (keratin K19; formerly also designated cytokeratin 19) of human glandular epithelia. he epitope has been localized on aa. 317-333(KAALEDTLAETEARFKS) of the alpha-helical fragment.Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
[1] Stasiak P.C., Lane E.B. Sequence of cDNA coding for human keratin 19. Nucleic Acids Res. 15:10058-10058(1987) [2] Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. Initial characte
