• Product NameIntegrin-linked protein kinase Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationCaprylic Acid Ammonium Sulfate Precipitation purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total Integrin-linked protein kinase polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Integrin-linked protein kinase protein
• Target NameIntegrin-linked protein kinase
• Alternative Names    59 kDa serine/threonine-protein kinase, ILK-1, ILK-2, p59ILK
• Accession No. Swiss-Prot#: Q13418
• UniprotQ13418
• Gene ID3611;
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

[1] "Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase."Hannigan G.E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M.G., Radeva G., Filmus J., Bell J.C., Dedhar S.Nature 379:91-96(1996

• Immunohistochemical analysis of paraffin-embedded 293T cells using #42192 at dilution of 1:100.
• Immunohistochemical analysis of paraffin-embedded humankidney using #42192 at dilution of 1:20.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting