The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.
[1]"Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues."He H., Dai F.Y., Yu L., She X., Zhao Y., Jiang J., Chen X., Zhao S.Y.Gene Expr. 10:231-242(2002) [2] Wong K., Hong W., Tang
