• Product NameVascular cell adhesion protein 1 Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationCaprylic Acid Ammonium Sulfate Precipitation purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total Vascular cell adhesion protein 1 polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Vascular cell adhesion protein 1 protein
• Target NameVascular cell adhesion protein 1
• Alternative Names    INCAM-100, CD_antigen=CD106 VCAM1, L1CAM
• Accession No. Swiss-Prot#: P19320
• UniprotP19320
• Gene ID7412;
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

[1]Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes.Osborn L., Hession C., Tizard R., Vassallo C., Luhowskyj S., Chi-Rosso G., Lobb R.Cell 59:1203-1211(1989) [2]Full length

• Immunohistochemical analysis of paraffin-embedded human colon cancer using #42485 at dilution of 1:20.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting