The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. Ref.26 Ref.37 Ref.40 Ref.45 Ref.46 Ref.49 Ref.52 Ref.53 Ref.56.The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
[1] "Cloning and sequencing of a human pancreatic tumor mucin cDNA."Lan M.S., Batra S.K., Qi W.-N., Metzgar R.S., Hollingsworth M.A.J. Biol. Chem. 265:15294-15299(1990) [2] "Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene en
