May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
[1]Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.Shapiro S.D., Kobayashi D.K., Ley T.J.J. Biol. Chem. 268:23824-23829(1993)[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., M
