DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
[1] Nucleotide sequence of the lig gene and primary structure of DNA ligase of Escherichia coli. Ishino Y., Shinagawa H., Makino K., Tsunasawa S., Sakiyama F., Nakata A.Mol. Gen. Genet. 204:1-7(1986) [2] Ally A., Ally D., Zhang X., Robichaud M., Backma
