• Product NameShc (phospho-Tyr317) rabbit pAb
• Host SpeciesRabbit
• PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
• ApplicationsWB
• Species ReactivityHuman,Mouse
• SpecificityThis antibody detects endogenous levels of Human Mouse Shc (phospho-Tyr317)
• Immunogen DescriptionSynthesized phosho peptide around human Shc (Tyr317)
• Alternative Names    SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
• Accession No. Swiss Prot:P29353
  GeneID:6464
• UniprotP29353
• Gene ID6464
• SDS-PAGE MW 66,52,46
• Concentration 1 mg/ml
• Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Storage -20˚C/1

• WB 1:1000-2000

SHC adaptor protein 1(SHC1) Homo sapiens This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011],

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting