• Product NameCREB Regulated Transcription Coactivator 2 Rabbit mAb
• Host SpeciesRecombinant Rabbit
• ClonalityMonoclonal antibody
• Clone No.S08-5F2
• IsotypeIgG
• PurificationAffinity Purified
• ApplicationsWB IHC
• Species ReactivityHuman,Rat
• Immunogen DescriptionA synthetic peptide of human TORC2
• ConjugatesUnconjugated
• ModificationUnmodification
• Alternative Names    TORC2; TORC-2
• Accession No. Swiss-Prot:Q53ET0
  GeneID:200186
• UniprotQ53ET0
• Gene ID200186
• Calculated MW Calculated MW:73 kDa,Observed MW:80 kDa
• Concentration 0.3 mg/ml
• Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Storage Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

• WB: 1/1000 IHC: 1/50

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

• Western blot detection of TORC2 in A549,HL-60,U251 cell lysates using TORC2 Rabbit mAb(1:1000 diluted).Predicted band size:73kDa.Observed band size:80kDa.
• Immunohistochemistry of TORC2 in paraffin-embedded Human breast cancer tissue using TORC2 Rabbit mAb at dilution 1/50

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting