• Product NameADAM10 Rabbit mAb
• Host SpeciesRabbit
• ClonalityMonoclonal
• IsotypeRabbit IgG
• PurificationAffinity-chromatography
• ApplicationsWB IP
• Species ReactivityHuman Mouse Rat
• SpecificityADAM10 Antibody detects endogenous levels of total ADAM10
• Immunogen DescriptionA synthesized peptide derived from human ADAM10
• Alternative Names    CDw156; CD156c; ADAM10; KUZ; MADM;
• Accession No. Uniprot:O14672
• UniprotO14672
• Formulation Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at +4˚C short term. Store at -20˚C long term. Avoid freeze / thaw cycle.

• WB 1:500~1:2000 IP 1:50

• The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.

The ADAM10 prodomain acts as a chaperone that stabilizes mature ADAM protein folding, and prevents target-protein shedding through inhibition of ADAM10 proteinase activity. Mature ADAM10 is the major α-secretase responsible for cleavage of Notch, APP, cadherins, and prion protein. The ADAM10 protein cleaves receptor tyrosine kinases and their associated ligands and displays a wide range of regulatory functions across related signaling pathways.

• Western blot analysis of ADAM10 expression in Jurkat cell lysate.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting