• Product NameAIRE Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• IsotypeIgG
• PurificationAffinity purification
• ApplicationsWB,IF
• Species ReactivityHuman,Mouse,Rat
• SpecificityThe antibody detects endogenous level of total AIRE protein.
• Immunogen TypePeptide
• Immunogen DescriptionA synthetic peptide of human AIRE (NP_000374.1).
• Target NameAIRE
• Alternative Names    AIRE;AIRE1;APECED;APS1;APSI;PGA1
• Accession No. Uniprot:O43918
  GeneID:326
• UniprotO43918
• Gene ID326
• SDS-PAGE MW 55kDa
• Concentration 1.0mg/ml
• Formulation PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Storage Store at -20˚C. Avoid freeze / thaw cycles.

• WB 1:500 - 1:2000
  IF 1:50 - 1:200

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

• Immunofluorescence analysis of NIH/3T3 cells using AIRE Rabbit pAb.
• Western blot analysis of extracts of various cell lines, using AIRE antibody.
• Immunofluorescence analysis of C6 cells using AIRE Rabbit pAb.
• Immunofluorescence analysis of HeLa cells using AIRE Rabbit pAb.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting