• Product NameRCAN1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• IsotypeIgG
• PurificationAffinity purification
• ApplicationsWB,IHC
• Species ReactivityHuman,Mouse,Rat
• SpecificityThe antibody detects endogenous level of total RCAN1 protein.
• Immunogen TypeRecombinant Protein
• Immunogen DescriptionRecombinant fusion protein of human RCAN1 (NP_004405.3).
• Target NameRCAN1
• Alternative Names    RCAN1;ADAPT78;CSP1;DSC1;DSCR1;MCIP1;RCN1
• Accession No. Uniprot:P53805
  GeneID:1827
• UniprotP53805
• Gene ID1827
• SDS-PAGE MW 31kDa
• Concentration 1.0mg/ml
• Formulation PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Storage Store at -20˚C. Avoid freeze / thaw cycles.

• WB 1:500 - 1:2000
  IHC 1:50 - 1:200

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants.

• Immunohistochemistry of paraffin-embedded human brain using RCAN1 Rabbit pAb.
• Immunohistochemistry of paraffin-embedded mouse brain using RCAN1 Rabbit pAb.
• Immunohistochemistry of paraffin-embedded mouse heart using RCAN1 Rabbit pAb.
• Immunohistochemistry of paraffin-embedded rat brain using RCAN1 Rabbit pAb.
• Immunohistochemistry of paraffin-embedded rat heart using RCAN1 Rabbit pAb.
• Immunohistochemistry of paraffin-embedded human liver using RCAN1 Rabbit pAb.
• Western blot analysis of extracts of various cell lines, using RCAN1 antibody.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting