• Product NameCRY1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity purification
• ApplicationsWB,IHC,ELISA
• Species ReactivityHuman, Mouse, Rat
• SpecificityThe antibody detects endogenous level of total CRY1 protein.
• Immunogen TypeRecombinant Protein
• Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human CRY1 (NP_004066.1).
• Target NameCRY1
• Alternative Names    PHLL1
• Accession No. Swiss-Prot: Q16526
  NCBI Protein: NP_031797.1
• UniprotQ16526
• Gene ID1407;
• Calculated MW 66kd
• Concentration 1.0mg/ml
• Formulation PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

• Predicted MW: 66kd
  Western blotting: 1:500~1:2000

Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45.
Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8.
Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.

• Western blot analysis of extracts from mouse brain tissue using CRY1 antibody #21414.
• Western blot analysis of extracts from 293T cells and Rat testis tissue using CRY1 Antibody #21414.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting