Brief: Histamine, an important bioactive molecule, is derived from thedecarboxylationof theamino acidhistidine. Most histamine in the body is generated in granules inmast cellsand inskin, lung and gastrointestinal tract, playing a pivotal role in allergic and inflammatory reactions. Histamine acts as a neurotransmitter within the central nervous system. The histaminergic neurons that secrete histamine are localized in small regions of the hypothalamus, but those neurons send axons widely throughout the brain. Histamine appears to modulate a number of important processes in the brain, including wakefulness, cognitive ability andfood consumption. Currently four histamine receptors (H1R-H4R) have been cloned and identified, all of which are G protein-coupled receptors. These different receptors are expressed on different cell types and work through different intracellular signaling mechanisms. Post mortem studies have revealedalterations in histaminergic system in neurological and psychiatric diseases. Melatoninis ahormone, produced by thepineal gland, a tinyendocrinegland situated at the center of the brain. Melatonin presents several ways of action in the regulation of seasonal reproduction, body weight and energy balance, antiaging, and promoting sleep.

Brief: Autophagyis the natural, regulated mechanism of the cell that disassembles unnecessary or dysfunctional components. Targeteddamaged cytoplasmicconstituents are isolated from the rest of the cell within a double-membraned vesicle known as anautophagosome.The autophagosome eventually fuses withlysosomesand the contents are degraded and recycled. Autophagy, cellular senescence, and apoptosis are three key responses of a cell facing a stress, correlating with each other. It has been reported that defects of autophagy are associated with genomic damage, metabolic stress, and tumorigenesis. The Autophagy Compound library by SAB contains 623 compounds with defined autophagy-inducing or -inhibitory activity, and is a useful tool for studying the roles of pro- and anti-autophagic molecules in cells as well as for use inin vitroapplications

Brief: The SABsHematopoietic Toxicity Compound Library is a focused collection of 104 compounds with defined and diverse hematopoietic toxicity, including myelosuppression, neutropenia, leukopenia, anemia, and many more. Bioactivity of all compounds were confirmed by bioassays, and reported by scientific literature. Some of them are FDA approved. The library is an essential tool for predictive toxicology screening and assay development.

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Brief: Serotoninor5-hydroxytryptamine(5-HT) is amonoamine neurotransmitter, derivative from the amino acidtryptophan, and mainly located in the enterochromaffin cells in the GI tract and central nervous system (CNS). It has a popular image as a contributor to feelings of well-being andhappiness, though its actual biological function is complex and multifaceted, modulating cognition, reward, learning, memory, and numerous physiological processes. Serotonin receptors, are a group ofG protein-coupled receptorandligand-gated ion channelsfound in thecentralandperipheral nervous systems. They can be divided into 7 families ofG protein-coupled receptorsexcept for the5-HT3receptor, aligand-gated ion channel, which activate anintracellularsecond messengercascade to produce an excitatory or inhibitory response. They mediate bothexcitatory and inhibitoryneurotransmission, influencing various biological and neurological processes. The serotonin receptors are the target of a variety of pharmaceutical and recreational drugs, including manyantidepressants,antipsychotics,anorectics,antiemetics,gastroprokinetic agents,antimigraine agents,hallucinogens, andentactogens. The Serotonin (5-HT) Compound Library by SAB, collecting 134 small chemicals targeting serotonin receptors, can be used for high throughput screening and high content screening, and drug discovery in neurological disorders.

Brief: Theadrenergic receptors or ad renoceptors are a class ofG protein-coupled receptorsthat are targets of manycatecholamineslikenorepinephrine(noradrenaline) andepinephrine(adrenaline) produced by the body, modulating cardiovascular , A unique collection of 117 bioactive compounds by SAB includes blockers, agonists, endogenous neuron transmitters, and approved drugs, and is an effective tool for screening or identifying recombinant orphan G-protein coupled receptors, new target identification, second screening, and other pharmacological applications.

Brief: Communication between and within neurons is critical for all functions of the nervous system, from development to aging, through health and disease. The last decade has seen huge advances in our knowledge of the molecular, cellular and systematic signaling pathways within the nervous system. There have been significant breakthroughs in studies on the signaling pathways that underlie neurogenesis, addiction and autism spectrum disorders, as well as the pathophysiology and treatment of mood disorders. G protein-coupledreceptors(GPCRs), including 5-HT receptors, histamine receptors, opioid receptors, are the largest family of signaling proteins to neuronal signaling. Changes in the GPCRs functioning can cause diseases many Neurological Disorders; Notch signaling is essential for proliferation, survival, self-renew, and differentiation of neural stem cells (NSCs). Notch signaling in neurons, glia and NSCs may be involved in pathological changes that occur in disorders such as stroke, Alzheimer��s disease and CNS tumors. Therefore, the potential of agents that target notch signaling could be used as therapeutic interventions for several different CNS disorders. The Neuronal Signaling Compound Library by SAB, containing 840 compounds targeting CNS signaling, can be used for high throughput screening and high content screening for new drugs in neurological disorders.

Brief: Changes in biological status (such as hypoxia, nutrients, drugs) usually cause the perturbations in the concentrations and fluxes of specific endogenous metabolites involved in a number of key disease-related or other specific cellular pathways. Extensive efforts in recent years have been focused on metabolic alterations in cancer, the products of intermediary metabolism have been a topic of considerable research interest.Cancer cells exhibit profound alterations in their metabolism. The quantitative measurement of the dynamic multiparametric metabolites, identification and quantification of intermediary metabolism can better help predict the tumor progress, understand the metabolic pathways and molecular mechanism of carcinogenesis. Current researches mainly focus on energy metabolism targeted compounds, such as nucleotides, amino acids, lipids, saccharide, etc. For example, alterations of cellular lipidomics (choline, phosphatidylcholine, cholesterol, etc.) reported in cancer provides a major opportunity to treat and prevent cancer; alterations of glucose metabolism (abnormal pyruvate, lactate, and isobutyric acid, etc.) in cancer cells, which also have become the hotspots in cancer research and therapeutics by targeting lipid metabolism and glucose metabolism. SABs collection of 665 endogenous metabolism-related compounds, Human Endogenous Metabolism Compound Library, can be used for research in endogenous metabolism-related diseases and drug screening.

Brief: Endocrine glandsare made ofa group of cellsthat secrete their products,hormones, directly into thebloodrather than through a duct. Hormones are transported by thecirculatory systemto target distant organs to regulatephysiologyandbehavior, such asmetabolism,growth, development,and reproduction. Hormones have diverse chemical structures, mainly of 3 classes:eicosanoids,steroids, andamino acid/protein derivatives. Endocrine disease is characterized by irregulated hormone release, inappropriate response to signaling, lack of a gland, or structural enlargement in a critical site such as the thyroid. The Endocrinology-Hormones Compound Library by SAB, containing 297 compounds targeting endocrine system, can be used for research in endocrine system, high throughput screening and high content screening for new drugs in endocrine diseases.

Brief: Given the central functional role that the ion channel superfamily plays in human physiology, its membrane localization, and the diverse tissue distribution of different members of the family, it represents an attractive potential target class for drug discovery. Ion channelsplay a fundamental role in the way cells communicate. This communication between cells allows for the orchestration of physical and mental activities in humans. A number of diseases occur when ion channels do not function properly. Some examples are diabetes, neuropathic pain, cardiovascular diseases, asthma, epilepsy, and neurodegenerative disease, etc. The Ion Channel Inhibitor Library by SAB, containing 362 compounds targeting ion channels, can be used for research in ion channel, high throughput screening and high content screening for ion channel drug discovery.