Brief: Gastroenteritis is inflammation of the lining of the stomach and small and large intestines. Most cases are infectious, although gastroenteritis may occur after ingestion of drugs and chemical toxins (eg, metals, plant substances). In the US, an estimated 1 in 6 people contracts foodborne illness each year. Worldwide, an estimated 1.5 million children die each year from infectious gastroenteritis. Compounds derived from natural products have demonstrated their effectiveness as therapeutic agents in different areas, such as cancer, aging, metabolic disorder, cardiovascular disease (controlling blood sugar), inflammation (gastroprotective effect), and neurologic disorders, etc. Gastrointestinal tract is where the natural products exert their bioactivities, such as modulating the movement of gastrointestinal tract, protecting stomach mucosa, keeping gut bacteria in balance, and interacting with intestinal immune system. Understanding the effects of natural products on gastrointestinal function is of significance to the treatment of related gastrointestinal diseases and drug screening. Anti-gastroenteritis Natural Product Library by SAB is a unique collection of 112 natural products related to gastroenteritis, an effective tool for research in gastric function and related diseases, drug screening.

Brief: Microscopic organisms, commonly known as microorganisms or microbes, are found all around us and even inside our bodies, including a massive range of organisms including bacteria, fungi, viruses, algae, archaea and protozoa. The vast majority of microbes on the earth pose no real threat to humans, plants or animals; in fact they actually work alongside humans to make world go round, aiding decomposition, decay and even helping us to digest our food.Microorganisms are renowned as a prolific source of natural products, making huge contribution to human health. The 1945 and 1952 Nobel Prizes in Physiology or Medicine were awarded for the discovery of penicillin and streptomycin, respectively. Six years later, the 2015 Nobel Prize in Physiology or Medicine was awarded to William C. Campbell and Satoshi Omura, and Youyou Tu for the discovery of avermectins and artemisinin, respectively, therapies that revolutionized the treatment of devastating parasite diseases.Among these four natural products awarded with Nobel Prizes, except for artemisinin, the other three all are microbial natural products. Streptomycesis the important source for natural medicines, the largestantibiotic-producing genus, producing antibacterial (vancomycin and daptomycin, etc.),antifungal (nystatin, amphotericin B, and natamycin), and antiparasitic drugs (Ivermectin), and also a wide range of otherbioactivecompounds used in other medical treatment, such asanti-cancer drugs (dactinomycin and bleomycin). Microbial Natural Product Library is a unique collection of 155 microbial natural products covering various chemical structures, such as ��-lactam, macrolides, aminoglycoside, polypeptides, Chloramphenicol, Tetracycline compounds, Anthraquinone, Benzene derivatives, quinone, Terpenoids, etc. This library can be used in rational drug design, virtual screening, and microbes classification, etc.

Brief: Hippocrates was to thank for the famous quote, ��Let food be thy medicine and medicine be thy food��. Hippocrates and the Ancient Greeks weren��t the only ones onto something when they studied the many medicinal properties of foods. Many traditional systems of healing which have been practiced throughout history �� including Ayurvedic Medicine and Traditional Chinese Medicine, for example �� have taught for thousands of years that food is medicine and a healthy diet is a powerful tool for protecting one��s health. In 2014, National Health and Family Planning Commission (NHFPC) of China released the draft ��Administrative Measures on the Catalogue of Substances Traditionally Considered as Both Food and Chinese Medicine�� for public consultation. There are 101 substances included in the Catalogue. Based on the food as medicine raw materials published by NHFPC and related literature, SAB carefully collects 305 compounds with safety guaranteed as Food as Medicine Library, which can be used for high throughput and high content screening for drug discovery

Brief: Except for Traditional Chinese Medicine (TCM) of Han Chinese, other ethnicities also approach health in their own ways. Among them, Yao people��s traditional medicine stands out as the most prominent one. Thanks to the unique natural geographic environment, many unique medicinal plant species were found by local people and made as Yao medicine to treat a variety of diseases, such as cancer, Lupus erythematosus, traumatic fracture, rheumatic diseases and women��s diseases. Medicinal baths also win them a good reputation in preventing and curing common diseases among the traditional Yao communities. From time immemorial, Yao people have known how to pick up a myriad of herbs to prepare various medicinal baths, which can not only wash down fatigue, but also enhance immunity, alleviate diseases and beautify skin. Thanks to thousands of years�� practice, Yao people have accumulated a stunning number of prescriptions. From minor ailments to diseases such as high blood pressure, each has a specific prescription

Brief: Polyphenolsare compounds with various potential biological properties such asantioxidants,anti-inflammatory, antineoplastic, antiaging, cardioprotective,anticancer, and antimicrobial properties. Natural polyphenols play an important role in cancer prevention and treatment by blocking cell cycle, inducing apoptosis, and inhibiting cell adhesion, migration, proliferation, and differentiation.Polyphenols are defined as compounds having at least one aromatic ring with one or more hydroxyl functional groups attached. Natural polyphenols include flavonoids, phenolic acids, lignans, tannins, stilbenes, curcumin, Coumarin, quinone, and other polyphenols. Natural Polyphenolic compound Library is a unique collection of 367 natural polyphenolic compounds, an effective tool for anti-cancer drug screening and high throughput screening (HTS) and high content screening (HCS).

Brief: Natural products are an unsurpassed source of chemical diversity and an ideal starting point for any screening program for pharmacologically active small molecules. Historically, natural products have been the most successful source of new drugs.From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Natural products have been proven to be successful modulators of difficult targets such as a range of antibacterial targets and, especially, protein�Cprotein interactions. Furthermore, many researchers consider natural products and their derivatives as a privileged tools for the study and manipulation of protein function. The SABsNatural Product Monomers (HTS) Library, a unique collection of 1680 natural products with known bioactivity, wide source, and high cost effectiveness, is a powerful tool for drug discovery, pharmacological study, and stem cell differentiation, etc

Brief: The blood�Cbrain barrier (BBB) is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). In its neuroprotective role, the blood�Cbrain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. Choosing the compounds that could penetrate BBB into the compound library targeting CNS is critical for CNS drug discovery. Based on the scientific literature, SAB collects 320 out of 5000 compounds as CNS-Penetrant Compound Library, which can be used for CNS-Penetrant related research and drug screening for CNS diseases

Brief: Scientists already found that the isomers or metabolites of many existing drugs show biological activity. For example, Levopropoxypheneis anantitussive, approved by FDA, but its enantiomer,Dextropropoxyphene, has an analgesic effect; L-sotalol is alpha-blocker while d-sotalol is antiarrythmic. Currently, knowledge of isomerism has helped us in introducing safer and more effective drug alternatives of the newer as well as existing drugs.These compounds that have rich pharmacological evaluation data are ideal as entry point for drug repurposing. The SABsSelected drug metabolites/isomers Library, a unique collection of 200 drug isomers/metabolites with a great diversity, can be used for drug screening

Brief: Fragment-based drug discovery (FBDD) has emerged in the past decade as a powerful tool for discovering drug leads. FBDD has played a role in discovery of at least 30 drugs that are in various stages of clinical development, and practitioners of FBDD can be found throughout the world in both academia and industry.Different from HTS, FBDD finds fragment-like hits (molecular weight less than 300) that usually bind with low affinity; therefore, sensitive detection methods are required, such as sensitive biophysical techniques: X-ray crystallography, NMR, Surface Plasmon Resonance (SPR), or mass spectrometry. This strategy offers several attractive features compared with traditional HTS or virtual screening, including higher hit rate, higher binding efficiency, and providing multiple starting points for further structural optimizations. In addition, because of the exponentially growing amount of information about one certain target, the effective utilization of bioinformatics and chemoinformatics is expected to contribute markedly toward the discovery of new drugs. The SAB sFragment Library collects 246 fragment-like small molecules for drug discovery

Brief: SABs Killer Collections include 277 synthetic and natural toxic substances that can alter cellular, metabolic and membrane functions, such as DNA/ RNA synthesis inhibitors, cytotoxic agents, immune suppressants, anti-proliferatives, endocrine disruptors and other agents. This special collection finds application in testing the sensitivity, development and profiling of new assays in high throughput screening (HTS) programs used in new drug discovery