Brief: Aprotein kinaseis akinaseenzymethat modifies other molecules, mostly proteins, by chemically addingphosphategroups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved insignal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzymeactivity, cellular location, or association with other proteins.Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis.More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis. The Tyrosine Kinase Inhibitors Library by SAB, containing 339 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases

Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy, however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 1081 compounds with known anti-tumor activity as Anticancer Active Compound Library that can be used for tumor-related research and anti-tumor drug screening

Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy, however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 822 anticancer drugs including FDA approved and compounds in clinical trial phases as Anticancer Drug Library that can be used for tumor-related research and anti-tumor drug screening

Brief: Cell differentiation is a multifaceted process that depends on complex regulatory networks that involve transcriptional, post-transcriptional and epigenetic regulation of gene expression. In cancer, this describes how much or how little tumor tissue looks like the normal tissue it came from. Well-differentiated cancer cells look more like normal cells and tend to grow and spread more slowly than poorly differentiated or undifferentiated cancer cells. Differentiation is used in tumor grading systems, which are different for each type of cancer. In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state also characterizes most cancer cells, especially leukemia cells. The induction of cancer cell differentiation is considered an alternative approach to elicit cell death and proliferation arrest. Differentiation therapy has mainly been developed to treat acute myeloid leukemia, notably with all-trans retinoic acid (ATRA). Numerous molecules from diverse natural or synthetic origins are effective alone or in association with ATRA in both in vitro and in vivo experiments. During the last two decades, pharmaceuticals and natural compounds with various chemical structures, including alkaloids, flavonoids and polyphenols, were identified as potential differentiating agents of hematopoietic pathways and osteogenesis. SAB collects 251 reported compounds inducing cancer cell differentiation as Promoting Cancer Cell Differentiation Compound Library, which can be used for high throughput and high content screening for drug discovery.

Brief: Cancer metabolismhas emerged as an important area ofresearchin recent years. Reprogramming of the cellular energy metabolism, essential for cancer cell proliferation and tumor development, constitutes an emerging hallmark of cancer and may serve as a biochemical basis for new therapeutic intervention. From the abnormal aerobic glycolysis effect in tumor cells was first discovered by German scientist Warburg in the early 1920s to now on all aspects of tumor metabolic activity (sugar, fat, amino acids, etc.) analysis and complex metabolic regulation network discovery, the study of tumor metabolism has entered into a more striking height. Distinct metabolic pathways (glycolysis and glutaminolysis), key regulators of aerobic glycolysis (AMPK, mTOR, HIF-1, c-Myc, p53, etc.), and key metabolism enzymes (PKM, HK, PFK, PK, IDH, GLS) might be the key targets for tumor therapeutics. Developing inhibitors targeting dysregulated metabolic enzymes and pathways may represent a promising strategy to overcome drug resistance in cancer therapy. A unique collection of 130 cancer cellular metabolism related compounds by SAB can be used for cancer related research and high throughput and high content screening for anti-cancer drugs.

Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy,however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 560 anti-cancer compounds currently in clinical trial phases based on published literatures and database to form this collection that can be used for high throughput screening and high content screening.

Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy,however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 313 approved anti-cancer drugs based on published literatures and database to form this collection that can be used as positive controls in biological cancer investigation and cancer correlation study

Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy,however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 3120 compounds with anti-tumor activity based on different characteristics and abnormal metabolism with cancer cells. All of these compounds are the small molecules modulating the metabolism, growth, invasion, and metastasis of tumor cells that can be used for tumor-related research and anti-tumor drug screening.

Brief: Cell signalingis part of any communication process that governs basic activities ofcellsand coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development,tissue repair, andimmunity, as well as normal tissuehomeostasis. Errors in signaling interactions and cellularinformation processingare responsible for diseases such ascancer,autoimmunity, anddiabetes.By understanding cell signaling, diseases may be treated more effectively. Inhibitor library is a unique collection of 3010 compounds, each of which has clear inhibitory targets. It is an effective tool for research in cell signaling pathways and related diseases, and high throughput screening and high content screening for new drugs

Brief: Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar). Too much sugar in the blood for a long period can lead to serious health problems. If left untreated, diabetes can cause many complications that would seriously impact the quality of life and shorten the life expectancy of the people with it. Currently there is no known cure to diabetes but people with diabetes can stay healthy by managing their disease through diet and the help of medicine. A unique collection of 179 small molecules affecting the development of diabetes is an effective tool for diabetes research and drug screening.