Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy,however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 560 anti-cancer compounds currently in clinical trial phases based on published literatures and database to form this collection that can be used for high throughput screening and high content screening.

Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy,however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 313 approved anti-cancer drugs based on published literatures and database to form this collection that can be used as positive controls in biological cancer investigation and cancer correlation study

Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy,however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 3120 compounds with anti-tumor activity based on different characteristics and abnormal metabolism with cancer cells. All of these compounds are the small molecules modulating the metabolism, growth, invasion, and metastasis of tumor cells that can be used for tumor-related research and anti-tumor drug screening.

Brief: Cell signalingis part of any communication process that governs basic activities ofcellsand coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development,tissue repair, andimmunity, as well as normal tissuehomeostasis. Errors in signaling interactions and cellularinformation processingare responsible for diseases such ascancer,autoimmunity, anddiabetes.By understanding cell signaling, diseases may be treated more effectively. Inhibitor library is a unique collection of 3010 compounds, each of which has clear inhibitory targets. It is an effective tool for research in cell signaling pathways and related diseases, and high throughput screening and high content screening for new drugs

Brief: Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar). Too much sugar in the blood for a long period can lead to serious health problems. If left untreated, diabetes can cause many complications that would seriously impact the quality of life and shorten the life expectancy of the people with it. Currently there is no known cure to diabetes but people with diabetes can stay healthy by managing their disease through diet and the help of medicine. A unique collection of 179 small molecules affecting the development of diabetes is an effective tool for diabetes research and drug screening.

Brief: An infection happens when a foreign organism enters a person's body and causes harm. These infectious organisms are known as pathogens. Examples of pathogens include bacteria, viruses, fungi, prions, and parasites. Some infections are mild and barely noticeable, but others are severe and life-threatening, and some are resistant to treatment. A unique collection of 605 bioactive small molecules with anti-bacterial, anti-virus, and anti-parasite capability was carefully selected by SAB for high throughput drug screening and new drug target identification in anti-infection research

Brief: Virus is a small infectious agent thatreplicatesonly inside the livingcellsof otherorganisms through various pathways, and causes the damage to the host cells. Common diseases caused by virus include smallpox, the common cold, chickenpox, influenza, shingles, hanta fever, herpes, etc. AIDS, polio, and Ebola are examples of life threatening serious viral diseases caused by HIV, poliovirus, and Ebola virus, respectively. The anti-virus compound library from SAB contains 157 compounds with anti-virus bioactivity, and is an appropriate tool for drug repurposing for new anti-virus drug discovery based on the fact that these viruses rely on common host cellular mechanisms to promote discrete stages of their life cycles

Brief: In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules (ATP) to specific substrates. This process is known as phosphorylation. The protein kinases make up the majority of all kinases and are widely studied. Aprotein kinasemodifies other molecules, mostly proteins, by phosphorylation to regulate the majority of cellular pathways, especially those involved insignal transduction. Various other kinases act on small molecules such aslipids,carbohydrates,amino acids, andnucleotides, either for signaling or to prime them for metabolic pathways. SABs Kinase Inhibitors Library, containing 900 kinase inhibitors, can be used for research in chemical genomics, pharmacological study, and drug screening for related diseases

Brief: Nuclear receptorsare a class ofproteins, different from membrane receptors located in the cell membrane,found within cells that are responsible for sensingsteroidandthyroidhormonesand certain other molecules.Nuclear receptors have the ability to directly bind toDNAand regulate the expression of adjacent genes, hence these receptors are classified astranscription factors, thereby controlling thedevelopment,homeostasis, andmetabolism of the organism. Over the last 15 years a growing number of nuclear receptors have been identified that coordinate genetic networks regulating lipid metabolism and energy utilization andunderlie the pathogenesis of metabolic diseases, such as obesity, type II diabetes, hypertension, and cardiovascular disease. SAB collects 239 reported compounds targeting nuclear receptors as Nuclear Receptor Compound Library, which can be used for research in nuclear receptor signaling and related diseases, and high throughput and high content screening for drug discovery

Brief: G-protein-coupled receptors(GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes that detectmoleculesoutside thecelland activate internalsignal transductionpathways and, ultimately, cellular responses.GPCRs are involved in nearly every aspect of animal life, from early development and heart function to neuronal activity. Mutations in GPCRs are linked to a number of human diseases. GPCRs are an important drug target and approximately 34%of the marketed drugs target 108 members of this family, with an additional 66 receptors targeted by agents that are/were in clinical trials.GPCR-based drug discovery remains active campaigns in major pharmaceutical companies. To date more than 140 orphan GPCRs, whose endogenous ligands are unknown, are the focus of an intense drug discovery effort in many programs. Specifically, the optimal ligands to GPCRs need to possess high affinity and specificity for the target protein, and reasonable membrane permeability for biological activity in whole cell assays and in vivo models. GPCR Compound Library from SAB, a focused small molecule libraries developed against particular GPCRs containing 730 GPCR-active agents for GPCR drug discovery