Brief: Theadrenergic receptors or ad renoceptors are a class ofG protein-coupled receptorsthat are targets of manycatecholamineslikenorepinephrine(noradrenaline) andepinephrine(adrenaline) produced by the body, modulating cardiovascular , A unique collection of 117 bioactive compounds by SAB includes blockers, agonists, endogenous neuron transmitters, and approved drugs, and is an effective tool for screening or identifying recombinant orphan G-protein coupled receptors, new target identification, second screening, and other pharmacological applications.

Brief: Communication between and within neurons is critical for all functions of the nervous system, from development to aging, through health and disease. The last decade has seen huge advances in our knowledge of the molecular, cellular and systematic signaling pathways within the nervous system. There have been significant breakthroughs in studies on the signaling pathways that underlie neurogenesis, addiction and autism spectrum disorders, as well as the pathophysiology and treatment of mood disorders. G protein-coupledreceptors(GPCRs), including 5-HT receptors, histamine receptors, opioid receptors, are the largest family of signaling proteins to neuronal signaling. Changes in the GPCRs functioning can cause diseases many Neurological Disorders; Notch signaling is essential for proliferation, survival, self-renew, and differentiation of neural stem cells (NSCs). Notch signaling in neurons, glia and NSCs may be involved in pathological changes that occur in disorders such as stroke, Alzheimer��s disease and CNS tumors. Therefore, the potential of agents that target notch signaling could be used as therapeutic interventions for several different CNS disorders. The Neuronal Signaling Compound Library by SAB, containing 840 compounds targeting CNS signaling, can be used for high throughput screening and high content screening for new drugs in neurological disorders.

Brief: Changes in biological status (such as hypoxia, nutrients, drugs) usually cause the perturbations in the concentrations and fluxes of specific endogenous metabolites involved in a number of key disease-related or other specific cellular pathways. Extensive efforts in recent years have been focused on metabolic alterations in cancer, the products of intermediary metabolism have been a topic of considerable research interest.Cancer cells exhibit profound alterations in their metabolism. The quantitative measurement of the dynamic multiparametric metabolites, identification and quantification of intermediary metabolism can better help predict the tumor progress, understand the metabolic pathways and molecular mechanism of carcinogenesis. Current researches mainly focus on energy metabolism targeted compounds, such as nucleotides, amino acids, lipids, saccharide, etc. For example, alterations of cellular lipidomics (choline, phosphatidylcholine, cholesterol, etc.) reported in cancer provides a major opportunity to treat and prevent cancer; alterations of glucose metabolism (abnormal pyruvate, lactate, and isobutyric acid, etc.) in cancer cells, which also have become the hotspots in cancer research and therapeutics by targeting lipid metabolism and glucose metabolism. SABs collection of 665 endogenous metabolism-related compounds, Human Endogenous Metabolism Compound Library, can be used for research in endogenous metabolism-related diseases and drug screening.

Brief: Endocrine glandsare made ofa group of cellsthat secrete their products,hormones, directly into thebloodrather than through a duct. Hormones are transported by thecirculatory systemto target distant organs to regulatephysiologyandbehavior, such asmetabolism,growth, development,and reproduction. Hormones have diverse chemical structures, mainly of 3 classes:eicosanoids,steroids, andamino acid/protein derivatives. Endocrine disease is characterized by irregulated hormone release, inappropriate response to signaling, lack of a gland, or structural enlargement in a critical site such as the thyroid. The Endocrinology-Hormones Compound Library by SAB, containing 297 compounds targeting endocrine system, can be used for research in endocrine system, high throughput screening and high content screening for new drugs in endocrine diseases.

Brief: Given the central functional role that the ion channel superfamily plays in human physiology, its membrane localization, and the diverse tissue distribution of different members of the family, it represents an attractive potential target class for drug discovery. Ion channelsplay a fundamental role in the way cells communicate. This communication between cells allows for the orchestration of physical and mental activities in humans. A number of diseases occur when ion channels do not function properly. Some examples are diabetes, neuropathic pain, cardiovascular diseases, asthma, epilepsy, and neurodegenerative disease, etc. The Ion Channel Inhibitor Library by SAB, containing 362 compounds targeting ion channels, can be used for research in ion channel, high throughput screening and high content screening for ion channel drug discovery.

Brief: Aprotein kinaseis akinaseenzymethat modifies other molecules, mostly proteins, by chemically addingphosphategroups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved insignal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzymeactivity, cellular location, or association with other proteins.Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis.More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis. The Tyrosine Kinase Inhibitors Library by SAB, containing 339 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases

Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy, however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 1081 compounds with known anti-tumor activity as Anticancer Active Compound Library that can be used for tumor-related research and anti-tumor drug screening

Brief: During the past decades, we have witnessed many landmark discoveries and successes in cancer research and therapy, however, cancer is still a major health problem for human beings, and it often physically and emotionally brings pains and difficulties to those living with it. Cancer cells remain undifferentiated (continue to divide, causing more damage, and invading new tissue), lack normal cell signaling responses (loss of contact inhibition and evasion of programmed cell death), contain abnormal changes (genetic abnormalities) in chromatin, have altered energy metabolism, and induce vascularization (ensure a steady supply of oxygen and nutrients). We carefully select 822 anticancer drugs including FDA approved and compounds in clinical trial phases as Anticancer Drug Library that can be used for tumor-related research and anti-tumor drug screening

Brief: Cell differentiation is a multifaceted process that depends on complex regulatory networks that involve transcriptional, post-transcriptional and epigenetic regulation of gene expression. In cancer, this describes how much or how little tumor tissue looks like the normal tissue it came from. Well-differentiated cancer cells look more like normal cells and tend to grow and spread more slowly than poorly differentiated or undifferentiated cancer cells. Differentiation is used in tumor grading systems, which are different for each type of cancer. In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state also characterizes most cancer cells, especially leukemia cells. The induction of cancer cell differentiation is considered an alternative approach to elicit cell death and proliferation arrest. Differentiation therapy has mainly been developed to treat acute myeloid leukemia, notably with all-trans retinoic acid (ATRA). Numerous molecules from diverse natural or synthetic origins are effective alone or in association with ATRA in both in vitro and in vivo experiments. During the last two decades, pharmaceuticals and natural compounds with various chemical structures, including alkaloids, flavonoids and polyphenols, were identified as potential differentiating agents of hematopoietic pathways and osteogenesis. SAB collects 251 reported compounds inducing cancer cell differentiation as Promoting Cancer Cell Differentiation Compound Library, which can be used for high throughput and high content screening for drug discovery.

Brief: Cancer metabolismhas emerged as an important area ofresearchin recent years. Reprogramming of the cellular energy metabolism, essential for cancer cell proliferation and tumor development, constitutes an emerging hallmark of cancer and may serve as a biochemical basis for new therapeutic intervention. From the abnormal aerobic glycolysis effect in tumor cells was first discovered by German scientist Warburg in the early 1920s to now on all aspects of tumor metabolic activity (sugar, fat, amino acids, etc.) analysis and complex metabolic regulation network discovery, the study of tumor metabolism has entered into a more striking height. Distinct metabolic pathways (glycolysis and glutaminolysis), key regulators of aerobic glycolysis (AMPK, mTOR, HIF-1, c-Myc, p53, etc.), and key metabolism enzymes (PKM, HK, PFK, PK, IDH, GLS) might be the key targets for tumor therapeutics. Developing inhibitors targeting dysregulated metabolic enzymes and pathways may represent a promising strategy to overcome drug resistance in cancer therapy. A unique collection of 130 cancer cellular metabolism related compounds by SAB can be used for cancer related research and high throughput and high content screening for anti-cancer drugs.