Brief: Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Furthermore, potassium channels are found in most cell types and control a wide variety of cell functions, such as regulation of cellular excitability, neurotransmitter release, protecting cardiac myocytes, and anti-arrhythmia function, and are involved in learning and memory process, and temperature control. Potassium channel blockers is a class of drugs that act by inhibition of potassium efflux through cell membranes, including inorganic ions (Cs, Ba) and organic molecules (TEA, 4-AP), toxins (scorpion venoms, snake venoms, and bee venoms), and potassium channel blockers in clinical use.

Brief: A calcium channel is an ion channel(plasma membrane protein) which shows selective permeability to calcium ions. Calcium channels constitute a large family of voltage- and ligand-operated ion channels. Calcium channels are ubiquitous, they can be found in almost any type of excitable (e.g., muscle, glial cells, neurons, etc.) and most unexcitable cells in a wide variety of species. Functions mediated by calcium channels include contraction of muscle, release of neurotransmitters and hormones by neurons and neuroendocrine cells, and control of gene transcription. They are targets for modulation by many intracellular signaling pathways including G proteins and phosphorylation. Calcium channels play pivotal roles in many human diseases, particularly of the cardiac and nervous systems, including pain, seizure, hypertension and migraine. Pharmacological blockers for some types of calcium channels are known, including clinically used drugs for hypertension and pain. In some cases such calcium channel blockers are highly selective for specific types of calcium channels, but there is great potential for developing more selective and more potent drugs targeting calcium channels. SABs Calcium Channel Library collects the reported calcium channel blockers and agonists, and is an ideal tool for screening more selective and potent drugs targeting calcium channels

Brief: Obesity has become the public health issue of the day��and for good reason. The data outline a dismal picture and a more foreboding future. The prevalence of obesity has doubled in adults and children and tripled in adolescents over the past 2 decades. Two thirds of Americans are overweight or obese. Each year in the United States, 400 000 deaths and $117 billion in health-care and related costs are attributable to obesity. Obesity is a complex, multi-factorial disease that develops from the interaction of genetic, social, behavioral, cultural, physiological, and metabolic factors. It is intimately linked to heart disease, sleep apnea, and certain cancers. Current main options for treatment of obesity including diet, physical exercise, behavioral therapy, and bariatric surgery have some degree of risk. Therefore, there is a strong need to develop a new effective and safe anti-obesity drug.Many pharmaceutical companies have invested substantial capital and labor to develop anti-obesity drugs; however, most of the anti-obesity drugs that have thus far been approved and marketed have ultimately been withdrawn because of their serious adverse effects. Scientists are trying to find and identify safe and effective anti-obesity bioactive ingredients from food or drugs, especially by inhibiting intestinal fat absorption, increasing fat cell metabolism, and enhancing the energy expenditure, such as lipase inhibitors, alpha-glucosidase inhibitors (��GI), and Maltase�\glucoamylase (MGA) inhibitors. Traditional pharmacological monotherapies for obesity, although initially successful in achieving weight loss, are often subject to counter-regulation. This is not surprising given the multiplicity and redundancy of mechanisms involved in appetite regulation and energy homeostasis. It is therefore pertinent to note that combination agents that are designed to simultaneously target more than one biological mechanism might ultimately be more effective in producing sustained weight loss and improvements in comorbidities. Based on the published literature, SAB carefully collects 85 compounds with anti-obesity activity as Anti-obesity Compound Library, which can be used for anti-obesity research and drug discovery

Brief: Although the Chinese herbal compound has achieved certain curative effect in clinical practice, the mechanism of action is hard to be elucidated through experiment due to their complicated components. This has seriously hindered further development and better clinical applications of Chinese medicine. Actually the pharmacological effect of Chinese medicine is realized through its active ingredients. For example, Artemisinin, the active ingredient extracted from a Chinese materia medica Artemisia annua, is the most effective antimalarial drug. Ginsenosides are a class of natural product steroid glycosides and triterpene saponins. Compounds in this family are found almost exclusively in the plant genus Panax (ginseng), which has a long history of use in traditional medicine. Therefore, it is a good and economical way to discover new chemical drugs based on active ingredients and leading compounds separating from Chinese herbal medicine and it may be an available path with less risk. With the continuous development of the traditional Chinese medicine industry in recent years, it is proved that traditional Chinese medicine (TCM) monomers have a marked effect for treating some diseases. Natural Compound Library in Chinese Pharmacopoeia by SAB consists of 564 natural products carefully selected from Chinese Pharmacopoeia (CP) Dictionary, including 246 active ingredients from traditional Chinese herb medicine, such as Danshen (Salvia miltiorrhiza), Eucommia ulmoides, Huangqi (Astragalus), etc. which is a powerful tool for research in antitumor, antibacterial, apoptosis, and autophagy. These Chinese medicine monomers consist of greatly diversified structures, such as Genistein, polyphenols, ��-Carotene, Ursolic acid, Flavonoids, and Saponins, etc. with known bioactivity information that will assist you in improving the drug screening success rate

Brief: Cancer is a well-recognized global health problem responsible for 7.6 million deaths (13% of all deaths) worldwide, which is expected to rise to 13.1 million by 2030. It has long been recognized that natural products represent the richest source of high chemical diversity, providing the basis for identification of novel scaffold structures that serves as starting points for rational anticancer drug design. According to a recent review, 49% of drugs were either natural products or their derivatives that are used in cancer treatment. Moreover, between the year 2005 and 2010, 19 natural product-based drugs have been approved, among which 7, 10 and 2 have been classified as natural product (NP), semi-synthetic NPs and NP-derived drugs, respectively. Natural products have served as an effective source of drugs and drug leads. SAB carefully collects 497 natural products from plants, animals, or microbes with known or potential antitumor activity, which is a powerful tool for your antitumor drug development and lead compounds screening

Brief: Gastroenteritis is inflammation of the lining of the stomach and small and large intestines. Most cases are infectious, although gastroenteritis may occur after ingestion of drugs and chemical toxins (eg, metals, plant substances). In the US, an estimated 1 in 6 people contracts foodborne illness each year. Worldwide, an estimated 1.5 million children die each year from infectious gastroenteritis. Compounds derived from natural products have demonstrated their effectiveness as therapeutic agents in different areas, such as cancer, aging, metabolic disorder, cardiovascular disease (controlling blood sugar), inflammation (gastroprotective effect), and neurologic disorders, etc. Gastrointestinal tract is where the natural products exert their bioactivities, such as modulating the movement of gastrointestinal tract, protecting stomach mucosa, keeping gut bacteria in balance, and interacting with intestinal immune system. Understanding the effects of natural products on gastrointestinal function is of significance to the treatment of related gastrointestinal diseases and drug screening. Anti-gastroenteritis Natural Product Library by SAB is a unique collection of 112 natural products related to gastroenteritis, an effective tool for research in gastric function and related diseases, drug screening.

Brief: Microscopic organisms, commonly known as microorganisms or microbes, are found all around us and even inside our bodies, including a massive range of organisms including bacteria, fungi, viruses, algae, archaea and protozoa. The vast majority of microbes on the earth pose no real threat to humans, plants or animals; in fact they actually work alongside humans to make world go round, aiding decomposition, decay and even helping us to digest our food.Microorganisms are renowned as a prolific source of natural products, making huge contribution to human health. The 1945 and 1952 Nobel Prizes in Physiology or Medicine were awarded for the discovery of penicillin and streptomycin, respectively. Six years later, the 2015 Nobel Prize in Physiology or Medicine was awarded to William C. Campbell and Satoshi Omura, and Youyou Tu for the discovery of avermectins and artemisinin, respectively, therapies that revolutionized the treatment of devastating parasite diseases.Among these four natural products awarded with Nobel Prizes, except for artemisinin, the other three all are microbial natural products. Streptomycesis the important source for natural medicines, the largestantibiotic-producing genus, producing antibacterial (vancomycin and daptomycin, etc.),antifungal (nystatin, amphotericin B, and natamycin), and antiparasitic drugs (Ivermectin), and also a wide range of otherbioactivecompounds used in other medical treatment, such asanti-cancer drugs (dactinomycin and bleomycin). Microbial Natural Product Library is a unique collection of 155 microbial natural products covering various chemical structures, such as ��-lactam, macrolides, aminoglycoside, polypeptides, Chloramphenicol, Tetracycline compounds, Anthraquinone, Benzene derivatives, quinone, Terpenoids, etc. This library can be used in rational drug design, virtual screening, and microbes classification, etc.

Brief: Hippocrates was to thank for the famous quote, ��Let food be thy medicine and medicine be thy food��. Hippocrates and the Ancient Greeks weren��t the only ones onto something when they studied the many medicinal properties of foods. Many traditional systems of healing which have been practiced throughout history �� including Ayurvedic Medicine and Traditional Chinese Medicine, for example �� have taught for thousands of years that food is medicine and a healthy diet is a powerful tool for protecting one��s health. In 2014, National Health and Family Planning Commission (NHFPC) of China released the draft ��Administrative Measures on the Catalogue of Substances Traditionally Considered as Both Food and Chinese Medicine�� for public consultation. There are 101 substances included in the Catalogue. Based on the food as medicine raw materials published by NHFPC and related literature, SAB carefully collects 305 compounds with safety guaranteed as Food as Medicine Library, which can be used for high throughput and high content screening for drug discovery

Brief: Except for Traditional Chinese Medicine (TCM) of Han Chinese, other ethnicities also approach health in their own ways. Among them, Yao people��s traditional medicine stands out as the most prominent one. Thanks to the unique natural geographic environment, many unique medicinal plant species were found by local people and made as Yao medicine to treat a variety of diseases, such as cancer, Lupus erythematosus, traumatic fracture, rheumatic diseases and women��s diseases. Medicinal baths also win them a good reputation in preventing and curing common diseases among the traditional Yao communities. From time immemorial, Yao people have known how to pick up a myriad of herbs to prepare various medicinal baths, which can not only wash down fatigue, but also enhance immunity, alleviate diseases and beautify skin. Thanks to thousands of years�� practice, Yao people have accumulated a stunning number of prescriptions. From minor ailments to diseases such as high blood pressure, each has a specific prescription

Brief: Polyphenolsare compounds with various potential biological properties such asantioxidants,anti-inflammatory, antineoplastic, antiaging, cardioprotective,anticancer, and antimicrobial properties. Natural polyphenols play an important role in cancer prevention and treatment by blocking cell cycle, inducing apoptosis, and inhibiting cell adhesion, migration, proliferation, and differentiation.Polyphenols are defined as compounds having at least one aromatic ring with one or more hydroxyl functional groups attached. Natural polyphenols include flavonoids, phenolic acids, lignans, tannins, stilbenes, curcumin, Coumarin, quinone, and other polyphenols. Natural Polyphenolic compound Library is a unique collection of 367 natural polyphenolic compounds, an effective tool for anti-cancer drug screening and high throughput screening (HTS) and high content screening (HCS).